Main Article Content
Abstract
Acne vulgaris is a common skin disorder caused by clogged pores and infection by Propionibacterium acnes. The use of synthetic chemicals in skincare products often leads to side effects, highlighting the need for safer and eco-friendly natural alternatives. Natural zeolite, particularly Lampung Natural Zeolite (ZAL), has potential as an antibacterial agent due to its porous structure and adsorption capacity. This study evaluates the effectiveness of ZAL as an active ingredient in clay mask formulations against P. acnes. ZAL was activated and purified, then formulated into masks with varying concentrations (2.5 g, 5 g, and 7.5 g). Characterization was conducted using IR, XRD, and SEM, while antibacterial activity was tested using the agar diffusion method. Activation improved crystallinity and increased silanol (Si–OH) groups, enhancing antibacterial performance. The 5 g zeolite formulation showed the largest inhibition zone, indicating optimal effectiveness. Overall, ZAL demonstrates strong potential as a natural antibacterial agent for facial mask products.
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References
- Alnuqaydan, A. M. (2024). The dark side of beauty: An in-depth analysis of the health hazards and toxicological impact of synthetic cosmetics and personal care products. Frontiers in Public Health, 12, 1439027.
- Amalia, F., & Purwamargapratala, Y. (2017). Penggunaan zeolit untuk stabilisasi formula ekstrak kulit buah delima sebagai antibakteri. Jurnal Kimia Dan Kemasan, 39(1), 25–30.
- Atikah, W. S. (2017). Karakterisasi zeolit alam gunung kidul teraktivasi sebagai media adsorben pewarna tekstil. Arena Tekstil, 32(1).
- Bohács, K., Faitli, J., Bokányi, L., & Mucsi, G. (2017). Control of Natural Zeolite Properties by Mechanical Activation in Stirred Media Mill. Archives of Metallurgy and Materials, Vol. 62, iss. 2B. https://doi.org/10.1515/amm-2017-0216
- Fajriani, N., Kurniawan, H., & Nugraha, F. (2022). Identify the rhodamin B on lipsticks in the market using thin layer chromatography (TLC) method. Journal Syifa Sciences and Clinical Research, 4(3).
- Ferreira, A. P., Almeida-Aguiar, C., Costa, S. P., & Neves, I. C. (2022). Essential oils encapsulated in zeolite structures as delivery systems (EODS): An overview. Molecules, 27(23), 8525.
- Florez, C., Restrepo-Baena, O., & Tobon, J. I. (2021). Effects of calcination and milling pre-treatments on natural zeolites as a supplementary cementitious material. Construction and Building Materials, 310, 125220.
- García-Villén, F., Souza, I. M. S., de Melo Barbosa, R., Borrego-Sánchez, A., Sánchez-Espejo, R., Ojeda-Riascos, S., & Iborra, C. V. (2020). Natural Inorganic Ingredients in Wound Healing. Current Pharmaceutical Design, 26(6), 621–641. https://doi.org/10.2174/1381612826666200113162114
- Ginting, S., Sari, D. P., Iryani, D. A., Darmansyah, D., Hanif, M., & Wardono, H. (2019). Sintesis Zeolit Lynde Type-A (LTA) Dari Zeolit Alam Lampung (Zal) Menggunakan Metode Step Change Temperature Of Hydrothermal Dengan Variasi SiO2/Al2O3 Diaplikasikan Untuk Dehidrasi Etanol. Journal of Chemical Process Engineering, 31–44.
- Hasanah, R. L., & Hasan, M. (2022). Deteksi lesi acne vulgaris pada citra jerawat wajah menggunakan metode k-means clustering. Indonesian Journal on Software Engineering (IJSE), 8(1), 46–51.
- Herlina, I., Krisnandi, Y. K., & Ridwan, M. (2024). Oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid over CuO and NiO modified natural sourced hierarchical ZSM-5. South African Journal of Chemical Engineering, 47, 75–82. https://doi.org/10.1016/j.sajce.2023.10.011
- Herlina, I., Krisnandi, Y. K., & Ridwan, M. (2025). Production of 2,5-furandicarboxylic acid (FDCA) from delignified rice husk waste over Cu and Ni metal-organic framework catalyst. Case Studies in Chemical and Environmental Engineering, 11, 101233. https://doi.org/10.1016/j.cscee.2025.101233
- Herlina, I., Puspitarum, D. L., Qadri, L. A., & Safitra, E. R. (2022). Pembuatan Biodiesel Berbahan Baku Fraksi Minyak Cpo (Crude Palm Oil) Parit Terkatalisis Zeolit Alam Lampung. Jurnal Inovasi Teknik Kimia, 7(1), 1–8. https://doi.org/10.31942/inteka.v7i1.5631
- Jayana, R., Fadlilah, I., & Prasadi, O. (n.d.). Karakteristik Sintesis Zeolit Dari Pemanfaatan Limbah Daun Nipah dan Alumunium Foil Bekas. METANA, 20(1), 1–13.
- Jha, A., & Jha, M. (2024). The Hidden Dangers: How Synthetic Organic Compounds Impact Health and the Environment. International Journal of Nursing Information, 3(2), 9–21.
- Król, M., Minkiewicz, J., & Mozgawa, W. (2016). IR spectroscopy studies of zeolites in geopolymeric materials derived from kaolinite. Journal of Molecular Structure, From Molecules to Molecular Materials, Biological Molecular Systems and Nanostructures, 1126, 200–206. https://doi.org/10.1016/j.molstruc.2016.02.027
- Maharani, T. A., Norhabibah, N., Wati, N. R. I., Putri, L. R., & Malahayati, S. (2024). Pengembangan Formulasi Clay Mask Stick Ekstrak Rumput Gandum (Triticum Aestivum L) Komoditas Lokal yang Berpotensi Sebagai Antioksidan: Development of Clay Mask Stick Formulation with Wheat Grass Extract (Triticum Aestivum L) a Local Commodity with Potensial as an Antioxidant. Jurnal Surya Medika (JSM), 10(2), 6–14.
- Mahfuzin, A. N., Respati, S. M. B., & Dzulfikar, M. (2020). Analisis Filter Keramik Berpori Berbasis Zeolit Alam Dan Arang Sekam Padi Dalam Menurunkan Kandungan Partikel Air Sumur Galian. JURNAL ILMIAH MOMENTUM, 16(1). https://doi.org/10.36499/mim.v16i1.3363
- Mariani, H., Mahdi, N., & Umam, K. (2023). BIOSINTESIS NANOPARTIKEL PERAK (Agnps) DENGAN EKSTRAK DAUN KIRINYUH (Chromolaena odorata) TERIMPREGNASI ZEOLIT DALAM MENGHAMBAT BAKTERI PENYEBAB JERAWAT. Jurnal Biosilampari: Jurnal Biologi, 5(2), 187–198.
- Mulyani, Y. W. T., Hidayat, D., & Isbiyantoro, Y. F. (2017). Ekstrak Daun Katuk (Sauropus androgynus (L) Merr) Sebagai Antibakteri Terhadap Propionibacterium acnes Dan Staphylococcus epidermis. JFL Jurnal Farmasi Lampung, 6(2).
- Nababan, Y. M., Rosmainar, L., & Angga, S. C. (2024). Sintesis Zeolit dari Abu Layang sebagai Media Lepas Lambat Senyawa Kalium. Bohr: Jurnal Cendekia Kimia, 3(01), 43–52.
- Neolaka, Y. A. B., & Kalla, E. B. (2024). Analisis bibliometric adsorpsi Pb (II) menggunakan adsorben berbasis zeolite alam. Jurnal Beta Kimia, 4(1), 68–76.
- Peixoto, P., Guedes, J. F., Rombi, E., Fonseca, A. M., Aguiar, C. A., & Neves, I. C. (2021). Metal Ion–Zeolite Materials against Resistant Bacteria, MRSA. Industrial & Engineering Chemistry Research, 60(35), 12883–12892. https://doi.org/10.1021/acs.iecr.1c01736
- Purwanjani, W., Lepangkari, J., & PP, E. A. (2021). Antibacterial activity of fennel essential oil against Propionibacterium acnes bacteria. Joseph: Journal of Science and Pharmacy, 1(01), 30–36.
- SN, R. A., Iskandar, N., & Sulardjaka, S. (2023). Pengaruh Kalsinasi Pelet Katalis Zeolit Alam Pada Kekuatan Mekanis Dengan Binder Kaolin. Jurnal Teknik Mesin, 11(4), 205–210.
- Tasić, Ž., Bogdanović, G., & Antonijević, M. (2019). Application of natural zeolite in wastewater treatment: A review. Journal of Mining and Metallurgy A: Mining, 55(1), 67–79.
- Vasam, M., Korutla, S., & Bohara, R. A. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 36, 101578.
- Yanti, R. N., Hambali, E., Pari, G., & Suryani, A. (2021). Analisis Karakteristik Fungsi Zeolit Alam Aktif Sebagai Katalis Setelah Diimpregnasi Logam Nikel. Jurnal Penelitian Hasil Hutan, 39(3), 138–147.
References
Alnuqaydan, A. M. (2024). The dark side of beauty: An in-depth analysis of the health hazards and toxicological impact of synthetic cosmetics and personal care products. Frontiers in Public Health, 12, 1439027.
Amalia, F., & Purwamargapratala, Y. (2017). Penggunaan zeolit untuk stabilisasi formula ekstrak kulit buah delima sebagai antibakteri. Jurnal Kimia Dan Kemasan, 39(1), 25–30.
Atikah, W. S. (2017). Karakterisasi zeolit alam gunung kidul teraktivasi sebagai media adsorben pewarna tekstil. Arena Tekstil, 32(1).
Bohács, K., Faitli, J., Bokányi, L., & Mucsi, G. (2017). Control of Natural Zeolite Properties by Mechanical Activation in Stirred Media Mill. Archives of Metallurgy and Materials, Vol. 62, iss. 2B. https://doi.org/10.1515/amm-2017-0216
Fajriani, N., Kurniawan, H., & Nugraha, F. (2022). Identify the rhodamin B on lipsticks in the market using thin layer chromatography (TLC) method. Journal Syifa Sciences and Clinical Research, 4(3).
Ferreira, A. P., Almeida-Aguiar, C., Costa, S. P., & Neves, I. C. (2022). Essential oils encapsulated in zeolite structures as delivery systems (EODS): An overview. Molecules, 27(23), 8525.
Florez, C., Restrepo-Baena, O., & Tobon, J. I. (2021). Effects of calcination and milling pre-treatments on natural zeolites as a supplementary cementitious material. Construction and Building Materials, 310, 125220.
García-Villén, F., Souza, I. M. S., de Melo Barbosa, R., Borrego-Sánchez, A., Sánchez-Espejo, R., Ojeda-Riascos, S., & Iborra, C. V. (2020). Natural Inorganic Ingredients in Wound Healing. Current Pharmaceutical Design, 26(6), 621–641. https://doi.org/10.2174/1381612826666200113162114
Ginting, S., Sari, D. P., Iryani, D. A., Darmansyah, D., Hanif, M., & Wardono, H. (2019). Sintesis Zeolit Lynde Type-A (LTA) Dari Zeolit Alam Lampung (Zal) Menggunakan Metode Step Change Temperature Of Hydrothermal Dengan Variasi SiO2/Al2O3 Diaplikasikan Untuk Dehidrasi Etanol. Journal of Chemical Process Engineering, 31–44.
Hasanah, R. L., & Hasan, M. (2022). Deteksi lesi acne vulgaris pada citra jerawat wajah menggunakan metode k-means clustering. Indonesian Journal on Software Engineering (IJSE), 8(1), 46–51.
Herlina, I., Krisnandi, Y. K., & Ridwan, M. (2024). Oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid over CuO and NiO modified natural sourced hierarchical ZSM-5. South African Journal of Chemical Engineering, 47, 75–82. https://doi.org/10.1016/j.sajce.2023.10.011
Herlina, I., Krisnandi, Y. K., & Ridwan, M. (2025). Production of 2,5-furandicarboxylic acid (FDCA) from delignified rice husk waste over Cu and Ni metal-organic framework catalyst. Case Studies in Chemical and Environmental Engineering, 11, 101233. https://doi.org/10.1016/j.cscee.2025.101233
Herlina, I., Puspitarum, D. L., Qadri, L. A., & Safitra, E. R. (2022). Pembuatan Biodiesel Berbahan Baku Fraksi Minyak Cpo (Crude Palm Oil) Parit Terkatalisis Zeolit Alam Lampung. Jurnal Inovasi Teknik Kimia, 7(1), 1–8. https://doi.org/10.31942/inteka.v7i1.5631
Jayana, R., Fadlilah, I., & Prasadi, O. (n.d.). Karakteristik Sintesis Zeolit Dari Pemanfaatan Limbah Daun Nipah dan Alumunium Foil Bekas. METANA, 20(1), 1–13.
Jha, A., & Jha, M. (2024). The Hidden Dangers: How Synthetic Organic Compounds Impact Health and the Environment. International Journal of Nursing Information, 3(2), 9–21.
Król, M., Minkiewicz, J., & Mozgawa, W. (2016). IR spectroscopy studies of zeolites in geopolymeric materials derived from kaolinite. Journal of Molecular Structure, From Molecules to Molecular Materials, Biological Molecular Systems and Nanostructures, 1126, 200–206. https://doi.org/10.1016/j.molstruc.2016.02.027
Maharani, T. A., Norhabibah, N., Wati, N. R. I., Putri, L. R., & Malahayati, S. (2024). Pengembangan Formulasi Clay Mask Stick Ekstrak Rumput Gandum (Triticum Aestivum L) Komoditas Lokal yang Berpotensi Sebagai Antioksidan: Development of Clay Mask Stick Formulation with Wheat Grass Extract (Triticum Aestivum L) a Local Commodity with Potensial as an Antioxidant. Jurnal Surya Medika (JSM), 10(2), 6–14.
Mahfuzin, A. N., Respati, S. M. B., & Dzulfikar, M. (2020). Analisis Filter Keramik Berpori Berbasis Zeolit Alam Dan Arang Sekam Padi Dalam Menurunkan Kandungan Partikel Air Sumur Galian. JURNAL ILMIAH MOMENTUM, 16(1). https://doi.org/10.36499/mim.v16i1.3363
Mariani, H., Mahdi, N., & Umam, K. (2023). BIOSINTESIS NANOPARTIKEL PERAK (Agnps) DENGAN EKSTRAK DAUN KIRINYUH (Chromolaena odorata) TERIMPREGNASI ZEOLIT DALAM MENGHAMBAT BAKTERI PENYEBAB JERAWAT. Jurnal Biosilampari: Jurnal Biologi, 5(2), 187–198.
Mulyani, Y. W. T., Hidayat, D., & Isbiyantoro, Y. F. (2017). Ekstrak Daun Katuk (Sauropus androgynus (L) Merr) Sebagai Antibakteri Terhadap Propionibacterium acnes Dan Staphylococcus epidermis. JFL Jurnal Farmasi Lampung, 6(2).
Nababan, Y. M., Rosmainar, L., & Angga, S. C. (2024). Sintesis Zeolit dari Abu Layang sebagai Media Lepas Lambat Senyawa Kalium. Bohr: Jurnal Cendekia Kimia, 3(01), 43–52.
Neolaka, Y. A. B., & Kalla, E. B. (2024). Analisis bibliometric adsorpsi Pb (II) menggunakan adsorben berbasis zeolite alam. Jurnal Beta Kimia, 4(1), 68–76.
Peixoto, P., Guedes, J. F., Rombi, E., Fonseca, A. M., Aguiar, C. A., & Neves, I. C. (2021). Metal Ion–Zeolite Materials against Resistant Bacteria, MRSA. Industrial & Engineering Chemistry Research, 60(35), 12883–12892. https://doi.org/10.1021/acs.iecr.1c01736
Purwanjani, W., Lepangkari, J., & PP, E. A. (2021). Antibacterial activity of fennel essential oil against Propionibacterium acnes bacteria. Joseph: Journal of Science and Pharmacy, 1(01), 30–36.
SN, R. A., Iskandar, N., & Sulardjaka, S. (2023). Pengaruh Kalsinasi Pelet Katalis Zeolit Alam Pada Kekuatan Mekanis Dengan Binder Kaolin. Jurnal Teknik Mesin, 11(4), 205–210.
Tasić, Ž., Bogdanović, G., & Antonijević, M. (2019). Application of natural zeolite in wastewater treatment: A review. Journal of Mining and Metallurgy A: Mining, 55(1), 67–79.
Vasam, M., Korutla, S., & Bohara, R. A. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 36, 101578.
Yanti, R. N., Hambali, E., Pari, G., & Suryani, A. (2021). Analisis Karakteristik Fungsi Zeolit Alam Aktif Sebagai Katalis Setelah Diimpregnasi Logam Nikel. Jurnal Penelitian Hasil Hutan, 39(3), 138–147.