AKTIVITAS MUKOLITIK EKSTRAK DAUN ILER (Coleus atropurpureus [L.] benth.) SECARA IN VITRO

Sulastri Herdaningsih; Dian Kartikasari

doi:10.31942/jiffk.v18i2.5960

AKTIVITAS MUKOLITIK EKSTRAK DAUN ILER (Coleus atropurpureus [L.] benth.) SECARA IN VITRO

Sulastri Herdaningsih, Dian Kartikasari

Abstract

Cough is a protective physiological mechanism to stimulate and cleanse the respiratory system of foreign objects that can cause infection. Traditional cough treatment is preferred because of the relatively low side ffects compared tochemical drugs. In some areas, Iler leaves are used as cough medicine. The purpose of this study was to determine the mucolytic activity of ethanol extract of Iler leaves on duck egg white which was added to the test solution every 15 minutes, namely at minutes 0,15,30,45, and 60. Viscosity measurements were carried out in the positive control group, negative control group, 3% group, 4,5% group and 6% group. The results obtained showed that Iler leaves extract was able to significantly reduce the viscosity of duck egg whites compare to the negative control. The ethanol extract of Iler leaves has mucolytic activity against duct egg white in vitro at a concetnration range of 3-6%.

Keywords

acetylcysteine; cough; ethanolic extract of slobber leaf; mucolytic

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References

Alam G., Mufidah., Massi N., Kurnia F., Rahim A., dan Usmar, 2012, Skrining Komponen Kimia Dan Uji Aktivitas Mukolitik Ekstrak Rimpang Bangle (Zingiber purpureum Roxb.) Terhadap Mukosa Usus Sapi Secara In Vitro, Majalah Farmasi dan Farmakologi, 16 (3): 123-127.

Amitjitraresmu, 1995, Uji Efek Anti Inflamasi Berbagai Ekstrak Daun Iler (Coleus atropurpureus L. Benth) dan Penelusuran Senyawa Aktifnya, Skripsi, FMIPA UNPAD, Bandung.

Azhari, A.N., Fitrianingsih S.P., dan Choesrina, R., 2015, Uji Aktivitas Mukolitik Ekstrak Etanol Daun Pare (Momordica charantia L.) Secara In Vitro, Proseding Penelitian SPeSIA, 1 (1): 73-78.

Gairola S, Gupta V, Bangsal P, Singh R, Maithani M, 2010, Herbal antitussives and expectorant-a review, International Journal of Pharmaceutical Sciences Review and Research, 5(2): 5

Kalita, B., 2013, Plant Essential Oils As Mosquito Repellent-A Review. International Journal of Research and Development in Pharmacy and Life Sciences, 3 (1): 741-747.

Koswara, S., 2009, Teknologi Pengolahan Telur (Teori dan Praktek), M-Brio Press, Bogor, Hal-4.

Kumala, S, 2009, Aktivitas Antibakteri Ekstrak Iler (Coleus atropurpureus L. Benth) terhadap Beberapa Bakteri Gram (+) dan Bakteri Gram (-), Skripsi, Fakultas Farmasi Universitas Pancasila.

Lubis, H.M., 2005, Batuk Kronik Dan Berulang (BKB) Pada Anak, Bagian Ilmu Kesehatan Anak, Fakultas Kedokteran,Universitas Sumatra Utara, 5.

Mutiatikum D, Alegantina S, dan Astuti Yun, 2010, Standardisasi Simplisia dari Buah Miana (Plectrantus seutellaroides (L)R. Bth) Yang Berasal dari Tiga Tempat Tumbuh Menado, Kupang, dan Papua, Buletin Penelitian Kesehatan, 38 (1): 1-16.

Sadowska, A.M., Verbraecken, J., Darquennes, K., dan De Backer W.A., 2006, Role of N-acetylcysteine in the management of COPD, International Journal of Chronic Obstructive Pulmonary Disease, 1(4): 425–434.

Saragih, Edward, 2011, Isolasi Identifikasi Senyawa Aktif Ekstrak Daun Iler (Coleus atropurpureus L. Benth), Skripsi, Fakultas Matematika dan Ilmu Pengetahuan Alam UNPAD, Bandung.

Setyawati, D.R., 2004, UJi Aktivitas Mukolitik Larut air dan Larut Etanol 70% dan Identifikasi Senyawa Kulit Akar Senggugu (Clerodendrum Serratum (L) Moon), Skripsi, Fakultas Farmasi Universitas Gadjah Mada.

Shiga, T., Shoji, K., Shimada, H., Hashida, S., Goto, F., dan Yoshihara, T., 2009, Effect of Light Quality on Rosmarinic Acid Content and Antioxidant Activity of Sweet Basil, Ocimum basilicum L, Plant Biotechnology, 26: 255-259.

Tamaweol, D., Ali, R.H., Simanjuntak, M.L. 2016. Gambaran Foto Toraks Pada Penderita Batuk Kronis di Bagian/SMF Radiologi FK Unsrat/RSUP Prof. Dr. R. D. Kandou Manado. Jurnal e-Clinic (eCl), 4 (1): 196-200.

Thomas, A., 2000, Tanaman Obat Tradisional 7, Penerbit Kanisius, Yogyakarta, 10

Williaman SS, 1955, Some Biological Effect of the Flavonoids, Journal of the American Pharmaceutical Assoc. Sci ., 44: 404-409.

Windriyati, Y.N, Murrukmihadi, M, dan Junita, N. R., 2007, Aktivitas Mukolitik In Vitro Ekstrak Etanolik Herba Meniran (Phyllanthus Niruri L) Terhadap Mukosa Usus Sapi, Jurnal Ilmu Farmasi dan Farmasi Klinik. 4 (1): 19-22.

DOI: http://dx.doi.org/10.31942/jiffk.v18i2.5960