Phytochemical Screening of Secondary Metabolites, Antioxidant and Antibacterial Activities of Kalangkala Plant (Litsea Angulata): A Review Article

Daipadli Daipadli, Ayu Shabrina, Sapto Yuliani, Nurkhasanah Nurkhasanah

Abstract


Litsea angulata, more commonly known as Kalangkala, is a type of plant that belongs to the Lauraceae family. Empirically, the plant has been used traditionally by local people for the treatment of boils, diarrhea, stomachache, dyspepsia, gastroenteritis, diabetes, insect bites, and anti-irritation. This review article aims to find out the results of phytochemical screening of metabolites from parts of Kalangkala plant with various solvents as well as the results of the tests of antioxidant and antibacterial activities that several researchers have carried out. The method used was a literature search on Google Scholar and Pubmed with the keywords kalangkala, Litsea angulata, phytochemical screening, antioxidant, and antibacterial. The results of this review showed that various solvents, such as water, ethanol, methanol, N-hexane, and ethyl acetate in seed, fruit flesh, bark, stem, and leave parts of Kalangakala plant produces different amounts of secondary metabolites. Secondary metabolites such as alkaloids, flavonoids, saponins, and tannins extracted well using etanol as a solvent due to their polarity. The results of the antioxidant activity showed that the part of kalangakala plant such as the bark of the tree, has a very good antioxidant activity of 2.41 ppm when tested using ethyl acetate solvent. Furthermore, the results of the antibacterial activity test show an inhibition of 50 mm on S. mutans bacteria when tested using ethanol solvent. In conclusion, kalangkala plant has secondary metabolites which act as antioxidants and antimicrobials that also potential to developed as traditional medicine.


Keywords


Kalangkala, Litsea angulata, phytochemical screening, antioxidant, antibacterial

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References


Agustina, S., Wiraningtyas, A. and Bima, K. (2016) ‘Skrining Fitokimia Tanaman Obat di Kabupaten Bima’, 4, pp. 71–76.

Aksara, R., Musa, W.J.A. and Alio, L. (2013) ‘Identifikasi Senyawa Alkaloid dari Ekstrak Metanol Kulit Batang Mangga (Mangifera indica L)’, Jurnal Entropi, 8(1), pp. 514–519.

Dwika, W. et al. (2016) ‘Identifikasi Senyawa Kimia Ekstrak Etanol Daun Kelor (Moringa oleifera L) di Bali’, Indonesia Medicus Veterinus Oktober, 5(5), pp. 464–473.

Fitriyanti, F., Qalbiyah, S. and Sayakti, P. (2020) ‘Identifikasi Kulit Batang Kalangkala (Litsea Angulata Bi) Secara Makroskopik, Mikroskopik, Dan Skrining Fitokimia’, Parapemikir : Jurnal Ilmiah Farmasi, 9(2), pp. 1–9. Available at: https://doi.org/10.30591/pjif.v9i2.1832.

Hafsari, A.R. et al. (2015) ‘Uji Aktivitas Antibakteri Daun Beluntas (Pluchea indica (L.) Less. ) Terhadap Propionibacterium acnes Penyebab Jerawat’, Istek, 9(1), pp. 142–161.

Ismail, A. and Hong, T.S. (2013) ‘Antioxidant Activity Of Selected Commercial Seaweeds’, (September 2002).

Jawetz, Melnick and Aldebergs (2005) ‘Mikrobiologi Kedokteran’, in Jakarta: Salamba Medika. 1st edn. Jakarta: Salamba Medika.

Kuspradini, H. et al. (2018) ‘Phytochemical, Antioxidant and Antimicrobial Properties of Litsea angulata Extracts [version 1; referees: 1 approved, 2 approved with reservations]’, F1000Research, 7, pp. 1–11. Available at: https://doi.org/10.12688/f1000research.16620.1.

Kuspradini, H., Putri, A.S. and Diana, R. (2020) ‘Toxicity, Antioxidant Ability and Inhibition of Oral Pathogens by Monoterpene-Rich Essential Oil of Litsea angulata Blume’, Agriculture and Natural Resources, 54(2), pp. 223–228. Available at: https://doi.org/10.34044/j.anres.2020.54.2.15.

Lestiani, L. (2008) Vitamin Larut Air. Jakarta: Universitas Airlangga.

Molyneux, P. (2004) ‘The Use of the Stable Free Radical Diphenylpicryl-hydrazyl (DPPH) for Estimating Antioxidant Activity’, Songklanakarin Journal of Science and Technology, 26 (December 2003), pp. 211–219. Available at: https://doi.org/10.1287/isre.6.2.144.

Mustikasari, K. and Ariyani, D. (2010) ‘The Phytochemistry Screening of Methanol Extract’, Sains dan Terapan Kimia, 4, pp. 131–136.

Parekh, J., Jadeja, D. and Chanda, S. (2005) ‘Efficacy of Aqueous and Methanol Extracts of Some Medicinal Efficacy of Aqueous and Methanol Extracts of Some Medicinal Plants for Potential Antibacterial Activity Plants’,Turk J Biol, 29(4).

Rahman, F.A., Haniastuti, T. and Utami, T.W. (2017) ‘Skrining Fitokimia dan Aktivitas Antibakteri Ekstrak Etanol Daun Sirsak (Annona muricata L.) pada Streptococcus mutans ATCC 35668’, Majalah Kedokteran Gigi Indonesia, 3(1), p. 1. Available at: https://doi.org/10.22146/majkedgiind.11325.

Ramadhan, H. et al. (2020) ‘Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Etanol 70% Biji Kalangkala (Litsea angulata Bl.) terhadap Bakteri Penyebab Jerawat Propionibacterium acnes Phytochemical Screening And Antibacterial Activities Of 70% Ethanol Extracts Of S’, Borneo Journal of Phamascientech, 04(01), pp. 60–70.

Rohama, R. and Melviani, M. (2021) ‘Formulasi dan Evaluasi Sediaan Obat Kumur (Mouthwash) dari Ekstrak Etanol Daun Kalangkala (Litsea angulata) sebagai Antiseptik Mulut’, Jurnal Surya Medika, 7(1), pp. 248–256. Available at: https://doi.org/10.33084/jsm.v7i1.2662.

Saputri, R. and Susiani, E.F. (2018) ‘Uji Aktivitas Antioksidan Ekstrak Etanol Buah dan Biji Buah Kalangkala (Litsea angulata) asal Kalimantan Selatan’, Borneo Journal of Pharmacy, 1(2), pp. 81–84. Available at: https://doi.org/10.33084/bjop.v1i2.370.

Schlegel, G.H. (1993) ‘General Microbiology’, in. England: Cambridge University Press.

Setyopuspito, P.A. (2017) ‘Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona Squamosa L) Terhadap Edema Kaki Tikus Putih Jantan Galur Wistar’, Jurnal Ilmiah Farmasi, 13(1), pp. 8–14. Available at: https://doi.org/10.20885/jif.vol13.iss1.art2.

Susiani, E.F. and Saputri, R. (2020) ‘Uji Aktivitas Antioksidan Ekstrak Etanol Daun Dan Kulit Batang Kalangkala (Litsea angulata) Asal Kalimantan Selatan’, Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan, 5(1), pp. 149–155. Available at: https://doi.org/10.36387/jiis.v5i1.406.

Tanaka, H. et al. (2009) ‘A New Amide from The Leaves and Twigs of Litsea auriculata’, Journal of Natural Medicines, 63(3), pp. 331–334. Available at: https://doi.org/10.1007/s11418-009-0323-y.




DOI: http://dx.doi.org/10.31942/jiffk.v20i2.9529

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