Preparasi Tablet Likuisolid Ramipril dengan Beberapa Pelarut dan Adsorben Neusilin-Aerosil

Nailatul Husna, Riska Rosita Dewi, Nunung Trisnaningrum, Yulias Ninik Windriyati

Abstract


Ramipril merupakan antihipertensi golongan Angiotensin Converting Enzym (ACE) inhibitor yang termasuk ke dalam BCS kelas II dengan karakteristik kelarutan rendah dan permeabilitas tinggi dalam gastrointestinal. Kelarutan obat yang rendah akan berakibat disolusi berjalan lambat, sehingga absorpsinya eratik dan bioavailabilitasya rendah. Diperlukan upaya untuk meningkatkan disolusi sehingga peningkatan bioavailabilitas ramipril dapat tercapai. Penelitian ini bertujuan untuk mengetahui karakteristik dan disolusi tablet likuisolid ramipril. Tablet likuisolid ramipril 10 mg dibuat menggunakan pelarut PEG 400, propilenglikol dan Tween 80 dan adsorben Neusilin-Aerosil 200. Semnilan formula telah dikembangkan dan dievaluasi parameter prakompresi seperti daya alir dan juga parameter paska kompresi. Semua formula sistem likuisolid yang dikembangkan menunjukkan aliran yang baik sesuai data standar. Semua tablet likuisolid memenuhi karakteristik tablet yang baik meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu hancur serta kandungan zat aktif. Uji disolusi dalam medium dapar fosfat pH 6,8 menunjukkan semua formula mampu melepaskan zat aktif lebih dari 80% pada menit ke-30 dan nilai DE30 lebih besar dibandingkan dengan tablet konvensional yang dibuat tanpa sistem likuisolid.

Keywords


dissolution; liquisolid; ramipril

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DOI: http://dx.doi.org/10.31942/jiffk.v20i2.8370

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