AKTIVITAS BAWANG PUTIH (Allium sativum L.) SEBAGAI AGEN ANTIBAKTERI

Debi Kristiananda, Juvita Lisu Allo, Veronica Arien Widyarahma, Lusiana Lusiana, Jeanne Magistra Noverita, Florentinus Dika Octa Riswanto, Dewi Setyaningsih

Abstract


Garlic (Allium sativum L.) has various potentials in overcoming diseases, one of which is as an antibacterial. The purpose of this study was to explore, analyze and review the activity of garlic (Allium sativum L.) as an antibacterial agent. This study uses a literature search method using search sites such as Google Scholar, Pubmed, ScienceDirect, AYU, NCBI, Elsevier, PlosOne, and Google Scholar. by entering keywords such as antibacterial, Garlic, and Allium sativum L. Garlic contains secondary metabolites that function as antibacterial agents such as alkaloids, tannins, saponins, flavonoids, allicin. Garlic has been shown to inhibit the growth of gram-positive and negative bacteria species Escherichia, Salmonella, Staphylococcus, Streptococcus, Klebsiella, Proteus, Bacillus, Clostridium, P. aeruginosa, K. pneumoniae and, Bifidobacterium lactis predominantly using the paper disk and well diffusion method.

 


Keywords


Allium sativum L; Antibacterial; Diffusion; Garlic

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References


Abidullah, M., Jadhav, P., Sujan, S.S., Shrimanikandan, A.G., Reddy, C.R., Wasan, R.K., 2021.

Potential Antibacterial Efficacy of Garlic Extract on Staphylococcus aureus, Escherichia coli,

and Klebsiella pneumoniae: An In vitro Study, J Pharm Bioallied Sci, 13(1), 590–594.

Abiy, E., Berhe, A., 2016, Anti-Bacterial Effect of Garlic (Allium sativum) against Clinical Isolates

of Staphylococcus aureus and Escherichia coli from Patients Attending Hawassa Referral

Hospital, Ethiopia. Journal of Infectious Diseases and Treatment, 02(02), 1–5.

Ali, M., Ibrahim, I.S., 2016, Phytochemical Screening and Proximate Analysis of Newbouldia

laevis and Allium sativum. Nigerian Journal of Animal Science, 18(1), 242-256–256.

Alirezaei, S., Godarzi, H., Moezi ghadim, N., Maheri, A., 2019, Antimicrobial Activity of Aqueous

Garlic Extract (Allium sativum) Against Porphyromonas gingivalis: An In-Vitro Study.

Journal of Research in Dental and Maxillofacial Sciences, 4(4), 17–22.

Altuntas, S., Korukluoglu, M., 2019, Growth and effect of garlic (Allium sativum) on selected

beneficial bacteri. Food Science and Technology, 39(4), 897–904.

Anggraini, A.L., Dwiyanti, R.D., Thuraidah, A., 2020, Garlic Extract (Allium sativum L.)

Effectively Inhibits Staphylococcus aureus and Escherichia coli by Invitro Test. Tropical

Health and Medical Research, 2(2), 61–68.

Anyamaobi, O.P., Wokem, G.N., Enweani Bessie, I., Okosa, N.J.A., Opara, C.E., Nwokeji, M.C.,

, Antimicrobial Effect Of Garlic And Ginger On Staphylococcus aureus From Clinical

Specimens In Madonna University Teaching Hospital, Nigeria. International Journal of

Recent Scientific Research, 11(3), 37840–37845.

Batiha, G.E.S., Beshbishy, A.M., Wasef, L.G., Elewa, Y.H.A., Al-Sagan, A.A., El-Hack, M.E.A.,

Taha, A.E., Abd-Elhakim, Y.M., Devkota, H.P., 2020, Chemical constituents and

pharmacological activities of garlic (Allium sativum L.): A review. Nutrients, 12(3), 1–21.

Benmeziane, F., Djermoune-Arkoub, L., Adamou Hassan, K., Zeghad, H., 2018, Evaluation of

antibacterial activity of aqueous extract and essential oil from garlic against some pathogenic

bacteria. International Food Research Journal, 25(2), 561–564.

Bernaldez, J.L., Vicencio, M.C.G., 2021, Antibacterial Activity of Soap Formulated from Garlic

(Allium sativum L.) Extract. Journal of Advances in Microbiology, 21(1), 63–67.

Bhatwalkar, S.B., Mondal, R., Krishna, S.B.N., Adam, J.K., Govender, P., Anupam, R., 2021,

Antibacterial Properties of Organosulfur Compounds of Garlic (Allium sativum). Frontiers in

Microbiology, 12(July), 1–20.

Booyens, J., Thantsha, M.S., 2013, Antibacterial effect of hydrosoluble extracts of garlic (Allium

sativum) against Bifidobacterium spp. and Lactobacillus acidophilus. African Journal of

Microbiology Research, 7(8), 669–677.

Cahayani, W.A., Tanuwijaya, C., Chi, L.X., Mulyastuti, Y., 2019, Antibacterial activity of garlic

(Allium sativum) extract and molecular docking studies of allicin. AIP Conference

Proceedings, 1-6.

Cushnie, T.P.T., Cushnie, B., Lamb, A.J., 2014. Alkaloids: An overview of their antibacterial,

antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial

Agents, 44(5), 377–386.

Daka, D., 2011, Antibacterial effect of garlic (Allium sativum) on Staphyloccus aureus: An in vitro

study, African Journal of Biotechnology, 10(4), 666–669.

Derbe, T., 2014, Antibacterial Activity Of Garlic Extracts Against Gram-Negative And Gram-

Positive Bacteria Tessema Derbe , Brey Kidane Mariam and Shilashi Badasa Department of

Chemistry, Adigrat University, P.O. box 50, Adigrat, Ethiopia 1(11), 730–734.

Enejiyon, S.O., Abdulrahman, A.A., Adedeji, A.S., 2020, Antibacterial Activities of the Extracts of

Allium sativum (Garlic) and Allium cepa (Onion) Against Selected Pathogenic Bacteria.

Tanzania Journal of Science, 46(3), 914–922.

Fatima, A., Ahmad, T., Khan, S.J., Deeba, F., Zaidi, N., 2011, Assessment of antibacterial activity

of in vitro and in vivo grown garlic (Allium sativum L.), Pakistan Journal of Botany,

(6),33029-22033.

Fowotade, A., Fowotade, A., Enaibe, B., Avwioro, G., 2017, Evaluating Toxicity Profile of Garlic

(Allium sativum) on the Liver, Kidney and Heart Using Wistar Rat Model. International

Journal of Tropical Disease & Health, 26(2), 1–12.

Fufa, B.K., 2019, Anti-bacterial and Anti-fungal Properties of Garlic Extract (Allium sativum): A

Review. Microbiology Research Journal International, 28(3), 1–5.

Garba, I., Umar, A., Abdulrahman, A., Tijjani, M., Aliyu, M., Zango, U., Muhammad, A., 2014,

Phytochemical and antibacterial properties of garlic extracts. Bayero Journal of Pure and

Applied Sciences, 6(2), 45.

Houshmand, B., Mahjour, F., Dianat, O., 2013, Antibacterial effect of different concentrations of

garlic (Allium sativum) extract on dental plaque bacteria. Indian Journal of Dental Research,

(1), 71–75.

Jahani Moghadam, F., Navidifar, T., Amin, M., 2014, Antibacterial Activity of Garlic (Allium

sativum L.) on Multi-Drug Resistant Helicobacter pylori Isolated From Gastric Biopsies.

International Journal of Enteric Pathogens, 2(2), 2–5.

Kshirsagar, M.M., Dodamani, A.S., Khobragade, V.R., 2018, Antibacterial activity of garlic extract

on cariogenic bacteria: An in vitro study, AYU (An International Quarterly Journal of

Research in Ayurveda), 39(3), 165–168.

Lawal, B., Shittu, O.K., Oibiokpa, F.I., Mohammed, H., Umar, S.I., Haruna, G.M., 2016,

Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum. Journal of

Acute Disease, 5(4), 296-301.

Li, G., Ma, X., Deng, L., Zhao, X., Wei, Y., Gao, Z., Jia, J., Xu, J., Sun, C., 2015, Fresh garlic

extract enhances the antimicrobial activities of antibiotics on resistant strains in vitro.

Jundishapur Journal of Microbiology, 8(5), 1–6.

Londhe, V.P., Gavasane, A.T., Nipate, S.S., Bandawane, D.D., Chaudhari, P.D., 2011, Review

Role of Garlic (Allium sativum) in Various Diseases : an Overview. Journal of

Pharmaceutical Research and Opinion, 4(January 2011), 129–134.

Lu, X., Rasco, B.A., Jabal, J.M.F., Eric Aston, D., Lin, M., Konkel, M.E., 2011, Investigating

antibacterial effects of garlic (Allium sativum) concentrate and garlic-derived organosulfur

compounds on Campylobacter jejuni by using fourier transform infrared spectroscopy, Raman

spectroscopy, and electron microscopy. Applied and Environmental Microbiology, 77(15),

–5269.

Mentri Kesehatan Republik Indonesia, 2016, Peraturan Menteri Kesehatan Republik Indonesia

Nomor 6 Tahun 2016 Tentang Formularium Obat Herbal Asli Indonesia, Jakarta: Kementrian

Kesehatan.

Moulia, M.N., Syarief, R., Iriani, E.S., Kusumaningrum, H.D., Suyatma, N.E., 2018, Antimikroba

Ekstrak Bawang Putih, Jurnal Pangan, 27(1), 55–66.

Mozaffari Nejad, A.S., Shabani, S., Bayat, M., Hosseini, S.E., 2014, Antibacterial effect of garlic

aqueous extract on Staphylococcus aureus in hamburger, Jundishapur Journal of

Microbiology, 7(11), 1–5.

Nugraha, S.E., Suryadi Achmad, Erly Sitompul, 2019. Antibacterial Activity of Ethyl Acetate

Fraction of Passion Fruit Peel (Passiflora edulis Sims) on Staphylococcus aureus and

Escherichia Coli, Indonesian Journal of Pharmaceutical and Clinical Research, 2(1), 7–12.

Nurtjahyani, S.D., Hadra, F., 2016, Antibacterial activity of garlic (Allium sativum) againts Gram-

positive bacteria isolated from tiger shrimp (Penaeus monodon), Asian Pacific Journal of

Tropical Disease, 6(1), 46–48.

Patil, P.. and, Pwar, 2016, Antibacterial activity of ginger (Zingiber officinale) and garlic (Allium

sativum L.) extracts on Escherichia coli. International Journal of Advanced Research and

Development, 1(5), 8–11.

Prati, P., Henrique, C.M., Souza, A.S. de, Silva, V.S.N. da, Pacheco, M.T.B., 2014, Evaluation of

allicin stability in processed garlic of different cultivars. Food Science and Technology

(Campinas), 34(3), 623–628.

Prihandani, S.S., 2015, Uji Daya Antibakteri Bawang Putih (Allium sativum L.) terhadap Bakteri

Staphylococcus aureus, Escherichia coli, Salmonella typhimurium dan Pseudomonas

aeruginosa dalam Meningkatkan Keamanan Pangan, Informatika Pertanian, 24(1), 53.

Purwantiningsih, T.I., Rusae, A., Freitas, Z., 2019. Uji In Vitro Antibakteri Ekstrak Bawang Putih

sebagai Bahan Alami untuk Menghambat Bakteri Staphylococcus aureus dan Escherichia

coli, Sains Peternakan, 17(1), 1–4.

Ratthawongjirakul, P., Thongkerd, V., 2016, Fresh garlic extract inhibits Staphylococcus aureus

biofilm formation under chemopreventive and chemotherapeutic conditions, Songklanakarin

Journal of Science and Technology, 38(4), 381–389.

Salima, J., 2015. Antibact Erial Activity of Garlic, J Majority, 2 (4), 30–39.

Sana Mukhtar, I.G., 2012, Antibacterial Activity of Aqueous and Ethanolic Extract of Garlic,

Cinnamon and Turmeric Against Escherichia coli ATCC 25922 and Bacillus subtilis DSM

, Thesis, Department of Environmental Sciences , Fatima Jinnah Women University,

–136.

Santhosha, S.G., Jamuna, P., Prabhavathi, S.N., 2013, Bioactive components of garlic and their

physiological role in health maintenance: A review, Food Bioscience, 3, 59–74.

Sieniawska, E., 2015, Activities of tannins-From in Vitro studies to clinical trials, Natural Product

Communications, 10(11), 1877–1884.

Simaremare, A.P.R., 2017, Perbedaan Aktivitas Antibakteri Ekstrak Tanaman Bawang Merah

(Allium cepa L ) dan Bawang Putih ( Allium sativum L ) pada Berbagai Konsentrasi terhadap

Bakteri Staphylococcus aureus In Vitro, Nommensen Journal of Medicine, 3(2), 52–57.

Škrovánková, S., Mlček, J., Snopek, L., Planetová, T., 2018,. Polyphenols and antioxidant capacity

in different types of garlic. Potravinarstvo Slovak Journal of Food Sciences, 12(1), 267–272.

Soltan, H.R., 2016, Extracted by Hydro-Distillationand Diethyl Ether Extraction Methods on Four

Pathogenic Bacteria. Advances in Plants & Agriculture Research, 4(2), 261–264.

Strika, I., Bašić, A., Halilović, N., 2017, Bulletin of the Chemists and Technologists of Bosnia and

Herzegovina Antimicrobial effects of garlic ( Allium sativum L.). Organic scientist, 47, 1-10.

Uzun, L., Dal, T., Kalcioglu, M.T., Yurek, M., Cibali Acikgoz, Z., Durmaz, R., 2019,

Antimicrobial Activity of Garlic Derivatives on Common Causative Microorganisms of the

External Ear Canal and Chronic Middle Ear Infections. Turkish Archives of

Otorhinolaryngology, 57(4), 161–165.

Viswanathan, V., Phadatare, A., Mukne, A., 2014, Antimycobacterial and antibacterial activity of

Allium sativum bulbs. Indian Journal of Pharmaceutical Sciences, 76(3), 256–261.

Wallock-Richards, D., Doherty, C.J., Doherty, L., Clarke, D.J., Place, M., Govan, J.R.W.,

Campopiano, D.J., 2014, Garlic revisited: Antimicrobial activity of allicin-containing garlic

extracts against Burkholderia cepacia complex. PLoS ONE, 9(12), 1–13.

Wolde, T., Kuma, H., Trueha, K., Yabeker, A., 2018, Anti-Bacterial Activity of Garlic Extract

against Human Pathogenic Bacteria. Journal of Pharmacovigilance, 06(01), 1–5.

Xie, Y., Yang, W., Tang, F., Chen, X., Ren, L., 2014. Antibacterial Activities of Flavonoids:

Structure-Activity Relationship and Mechanism. Current Medicinal Chemistry, 22(1), 132–

Yadav, S., Trivedi, N., Bhatt, J., 2015. Antimicrobial activity of fresh garlic juice: An in vitro

study. AYU (An International Quarterly Journal of Research in Ayurveda), 36(2), 203.

Yetgin, A., Canli, K., Altuner, E.M., 2018. Comparison of Antimicrobial Activity of Allium

sativum Cloves from China and Taşköprü, Turkey. Hindawi, 1-5.




DOI: http://dx.doi.org/10.31942/jiffk.v19i1.6683

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