PENINGKATAN EFEK ANTIHIPERTENSI KAPTOPRIL OLEH EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT

Devi Nisa Hidayati, Yance Anas, Siti Nurikha

Abstract


ABSTRACT
Hypertension is one of the degenerative disease of health problem  in among people.
Bilimbi leaves (Averrhoa bilimbi L.) is one of plants which is have antihypertension effect and
contains phytol, dietil phtalat, flavonoid.  This research is aimed  to know influence of ethanol
extract of bilimbi leaves (EEBL)   through its on the increase of the antihypertensive effect of
captopril in hypertensive rats.
This research used a pre-test and post-test matched control group design.   Sample were 30
male Wistar rats  treated with MSG 100 mg/kgBW/day (po) for 14 days to induce hypertension.
Hypertensive rats were divided into six treatment groups are  hypertension control group (0.5%
CMC-Na 12.5 mL/kgBW/day) and positive control group (captopril 2.5 mg/kgBW/day), and
treatment hypertensive rats EEBL (60 and 120) mg/kgBW/day, combination of EEBL-captopril
(60+2.5)mg/kgBW/day and combination EEBL-captopril (120+2.5) mg/kgBW/day.  Suspension
test were given for 14 days. Observed data is a decrease in blood pressure after giving of the
suspension test. Data analysis was performed with the parametric t-test paired and nonparametric
Wilcoxon with 95% level of confidence.
The result shows that MSG can be as inducer of hypertension. EEBL (60 and 120)
mg/kgBW/day has antihypertensive effect. The increase antihypertensive effect of captopril on
systolic blood pressure is showed in the treatment EEBL 120 mg/kgBW/day.   
Keywords: Hypertension, Monosodium glutamate, Averrhoa bilimbi L.

Full Text:

PDF


DOI: http://dx.doi.org/10.31942/jiffk.v12i2.1410

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Devi Nisa Hidayati, Yance Anas, Siti Nurikha

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

INDEXED BY :

 Google Scholar   Google Scholar Road Google Scholar Google Scholar Sinta


Alamat kami di :

Fakultas Farmasi Universitas Wahid Hasyim

Jl. Raya Manyaran-Gunungpati, Nongkosawit, Kec. Gn. Pati, Kota Semarang, Jawa Tengah 50224, Indonesia
Handphone: +62812-2946-5952
Email: jiffk@unwahas.ac.id

 

 
 

Visitor JIFFK Unwahas