Nanoformulations of Plant Extracts for Psoriasis Treatments: A Systematic Review

Abstract

Psoriasis is a chronic inflammatory skin disorder that affects the cutaneous and immune systems. The inflammatory responses play a vital role in the pathophysiology and progression of psoriasis. The disease manifests as flaking, hardened, and erythematous plaques. Herbal medicines from plant extracts offer a promising treatment for psoriasis with extensive benefits and minimum toxicity. Nanoformulations have been expansively utilized for improving topical drug absorption from plant extracts because of the ability to increase epithelium permeability and bioavailability, thus extending the bioactivity of drugs in the subcutaneous skin. This study aim to illustrate excellent evidence of the effectiveness and safety of plant extracts nanoformulations for psoriasis management to encourage its clinical application. Numerous databases were systematically explored, including PubMed, ScienceDirect, SpringerLink, Scopus, and Google Scholar, from December 2024 to January 2025 using the keywords "Nano AND Plant Extracts AND Psoriasis". Overall, only six (6) articles met the inclusion criteria. Nanoformulations appear nontoxic and effective in psoriasis treatment and have a significant positive effect on the pathophysiology of the disease. Research reveals that it eliminates skin lesions, reduces the severity of pruritus, and lowers the recurrence rate. This study will give insight into the valuable medicinal plants and provide a reference for future studies on psoriasis treatment. A precise pharmacological and clinical evaluation of these medicinal plants is mandatory to assess their active compounds