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Abstract
Kandidiasis oral merupakan salah satu kelainan pada mukosa rongga mulut yang disebabkan oleh Candida albicans. Candida albicans adalah flora normal rongga mulut yang dapat berubah menjadi patogen bila dalam diri pejamu mengalami perubahaan. kandidiasis dapat terlihat dari munculnya lesi pada rongga mulut, tetapi lokasi yang paling sering adalah mukosa. Daun Jeruju memiliki aktivitas sebagai anti jamur. Potensi anti jamur daun jeruju dapat dimanfaatkan dalam formula sediaan mouthwash. Mouthwash merupakan sediaan yang jernih, mengandung senyawa antiseptik, pemanis dan memiliki rasa serta aroma yang menyegarkan. Pada penelitian ini akan dilakukan formulasi nanomouthwash fraksi etil asetat ekstrak methanol daun jeruju dengan kombinasi sorbitol sebagai pemanis dan gliserin sebagai humektan, serta menguji aktivitas formula terbaik terhadap Candida albicans. Hasil menunjukkan bahwa diantara ketiga formula yang memiliki karakteristik fisik yang baik adalah formula I dan hasil uji aktivitas sediaan terhadap candida albicans menunjukkan zona hambat sebesar 9,27 ±1,291 mm
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References
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- Katya M.Aguilar-Perez, Dora I, Medina, Roberto Parra-Saldivar, H.M.Ni. (2022) ‘Nano-Size Characterization and Antifungal Evaluation Essential Oil Molecules-Loaded Nanoliposomes’.
- N., S., Chandrakala, V. and Srinivasan, S. (2022) ‘Review on: Effect of Oil, Surfactant and Cosurfactant on Microemulsion’, International Journal of Current Pharmaceutical Research, 14(4), pp. 23–27. Available at: https://doi.org/10.22159/ijcpr.2022v14i4.2011.
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- van Swaaij, B.W.M. et al. (2024) ‘Fluoride, pH Value, and Titratable Acidity of Commercially Available Mouthwashes’, International Dental Journal, 74(2), pp. 260–267. Available at: https://doi.org/10.1016/j.identj.2023.09.002.
References
Adjeng, A.N.T. et al. (2023) ‘OPTIMATION OF SORBITOL, GLYCERINE, AND XANTHAN GUM COMBINATION IN MUCOLITIC SYRUP OF Hibiscus rosa-sinensis LEAVES EXTRACT USING MIXTURE DESIGN (D-OPTIMAL)’, Rasayan Journal of Chemistry, 16(1), pp. 509–518. Available at: https://doi.org/10.31788/RJC.2023.1618130.
Andriani, D., Revianti, S. and Prananingrum, W. (2020) ‘Identification of compounds isolated from a methanolic extract of acanthus ilicifolius leaves and evaluation of their antifungal and antioxidant activity’, Biodiversitas, 21(6), pp. 2521–2525. Available at: https://doi.org/10.13057/biodiv/d210625.
Irawanto, R. and Mangkoedihardjo, S. (2015) ‘Fitoforensik Logam Berat (Pb Dan Cd) Pada Tumbuhan Akuatik (Acanthus Ilicifolius Dan Coix Lacryma-Jobi)’, Jurnal Purifikasi, 15(1), pp. 53–66. Available at: https://purifikasi.id/index.php/purifikasi/article/view/25.
Katya M.Aguilar-Perez, Dora I, Medina, Roberto Parra-Saldivar, H.M.Ni. (2022) ‘Nano-Size Characterization and Antifungal Evaluation Essential Oil Molecules-Loaded Nanoliposomes’.
N., S., Chandrakala, V. and Srinivasan, S. (2022) ‘Review on: Effect of Oil, Surfactant and Cosurfactant on Microemulsion’, International Journal of Current Pharmaceutical Research, 14(4), pp. 23–27. Available at: https://doi.org/10.22159/ijcpr.2022v14i4.2011.
Nusaibah, Pangestika, W. and Herry (2021) ‘Characteristics of Acanthus ilicifolius Leaves as Raw Materials for Drugs and Cosmetics’, Journal of Pharmaceutical, Biological and Chemical Sciences, 12(1), pp. 1–12. Available at: https://doi.org/10.33887/rjpbcs/2021.12.1.1.
Prananingrum, W. et al. (2022) ‘The effect of effervescent acanthus ilicifolius l. extract on antifungal properties and flexural strength acrylic’, Odonto : Dental Journal, 9(2), p. 310. Available at: https://doi.org/10.30659/odj.9.2.310-318.
Ragavan, P. et al. (2015) ‘Taxonomy and distribution of species of the genus acanthus (Acanthaceae) in mangroves of the Andaman and Nicobar Islands, India’, Biodiversitas, 16(2), pp. 225–236. Available at: https://doi.org/10.13057/biodiv/d160218.
van Swaaij, B.W.M. et al. (2024) ‘Fluoride, pH Value, and Titratable Acidity of Commercially Available Mouthwashes’, International Dental Journal, 74(2), pp. 260–267. Available at: https://doi.org/10.1016/j.identj.2023.09.002.